Minakshi Das1, Kyu Hwan Shim1
Department of BioNano Technology, Gachon University, Seongnam 461-701, Korea.
Toxicology and Environmental Health Sciences. 2011, 3(4), 193-205
Gold nanoparticles are widely used in many fields as preferred materials for their unique optical and physical properties, such as surface plasmon oscillations for labeling, imaging, and sensing. Recently, many advancements were made in biomedical applications with better biocompatibility in disease diagnosis and therapeutics. Au-NPs could be prepared and conjugated with many functionalizing agents, such as polymers, surfactants, ligands, dendrimers, drugs, DNA, RNA, proteins, peptides and oligonucleotides. This review addressed the use of gold nanoparticles and the surface functionalization with a wide range of molecules, expanding and improving gold nanoparticles in targeting drugs for photothermal therapy with reduced cytotoxic effcts in various cancers, gene therapy and many other diseases. Overall, Au-NPs would be a promising vehicle for drug delivery and therapies.